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FLASH GENE
Symbol OXT contributors: mct/npt - updated : 18-01-2014
HGNC name oxytocin, prepropeptide
HGNC id 8528
DNA
TYPE functioning gene
STRUCTURE 0.89 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map pter - AVP /OXT , PDYN - D20S5 , D20S6 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 512 12.7 125 - 2011 21315262
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine     Homo sapiens
Nervousbraindiencephalonhypothalamus   Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium (mucosa)   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Skeletonosteoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to murine Oxt
homolog to C..elegans F17C11.2
Homologene
FAMILY
  • vasopressin/oxytocin family
  • CATEGORY signaling hormone , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • contracting smooth muscle during parturition and lactation
  • involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour as well as in the regulation of water excretion and cardiovascular functions
  • modulates the NPY response to ghrelin, whereas it is unable to produce direct inhibitions of basal circulating NPY levels
  • anabolic regulator of bone mass, with potential implications for osteoporosis therapy
  • can facilitate amygdala-dependent, socially reinforced learning and emotional empathy in men
  • potentially acting as a carbohydrate-specific inhibitor of feeding
  • primitive neurohypophyseal hormone that plays a primary and indispensible role in mammalian lactation
  • OXT produced from osteoblasts in response to estrogen acts upon its receptor to exert a potent anabolic action
  • can act as a neurotransmitter that reduces anxiety, promotes social behaviors and regulates food intake
  • OXT could be essential for the normal development of the serotoninergic system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text carrier protein neurophysin I
    PATHWAY
    metabolism
    signaling hormonal , signal transduction
    posterior pituitary hormone oxytocin
    a component
  • neurophysin 1 binding specifically to oxytocin which are two proteins encoded by the same gene
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • neurophysin 1 binding specifically to oxytocin
  • interacting with SYT4 (SYT4 negatively regulates oxytocin exocytosis, and dietary obesity is associated with increased vesicle binding of SYT4 and thus enhanced negative regulation of oxytocin release)
  • relationship between FTO and OXT could thus be an important mechanism through which FTO exerts its effect on energy balance
  • GNAI2 plays an essential role in OXT and EGF signaling to induce prostate cancer cell migration
  • cell & other
    REGULATION
    repressed by SYT4 (negative regulation of SYT4 on oxytocin release represents a hypothalamic basis of neuropeptide exocytosis in controlling obesity and related diseases)
    Other activated while it is being transported along the axon to the posterior pituitary
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS