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FLASH GENE
Symbol THSD3 contributors: - updated : 28-02-2006
HGNC name thrombospondin, type I domain-containing 3
HGNC id 23176
DNA
TYPE functioning gene
STRUCTURE 24.00 kb     7 Exon(s)
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure five binding sites for Sp1 and seven for MZF-1, three for USF and several for GATA-2, HSF-2, CREB, SRY
MAPPING cloned Y linked N status provisional
regionally located within ARVD1 critical region
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2942 63.9 571 - Rossi
- splicing 3047 - 483 - Rossi
an additional exon at the 5' end initiating translation from a downstream start codon
- splicing 2596 - 292 - Rossi
lacks an in-frame coding exon
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivefemale systemplacenta  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an hydrophobic signal peptide
  • 17 putative glycosylation sites
  • a thrombospondin type I repeat (TSR) domain
  • an AMOP domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY isthmin family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION may be involved in adhesion processes
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS