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FLASH GENE

Symbol

SLC30A6

contributors: mct - updated : 19-09-2015

HGNC name	solute carrier family 30 (zinc transporter), member 6
HGNC id	19305

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	58.27 kb     14 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001193514 13 - 4776 - 438 - 2002 11997387 NM_001193513 15 - 4965 - 501 - 2002 11997387 NM_017964 14 - 4845 - 461 - 2002 11997387

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine           stomach         Nervous brain hindbrain medulla oblongata     Reproductive male system testis       Respiratory lung         Urinary kidney

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a histidine-rich region which is a ligand for zinc
	an aspartate-rich region which is a potential ligand for zinc

HOMOLOGY

Homologene

FAMILY	cation diffusion facilitator (CDF) transporter family
	SLC30A subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi

basic FUNCTION

involved in zinc transport out of the cytoplasm, may be by sequestration into an intracellular compartment

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimerizing with SLC30A5 (cytosolic C-terminal tail of SLC30A5 is important in determining SLC30A6 as a partner molecule for heterodimer formation)

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   in preclinical stage of AD hippocampus/parahippocampal gyrus constitutional     --low   in milk zinc deficiency that are linked to low levels of the SLC30A5 and SLC30A6 zinc transporters

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS