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FLASH GENE
Symbol PLEKHG5 contributors: mct - updated : 04-06-2016
HGNC name pleckstrin homology domain containing, family G (with RhoGef domain) member 5
HGNC id 29105
DNA
TYPE pseudogene
STRUCTURE 53.92 kb     22 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 4643 - 1006 - 2001 11704860
22 - 5221 - 1083 - 2001 11704860
22 - 4761 117.4 1062 - 2001 11704860
21 - 4715 - 1006 - 2001 11704860
21 - 4698 - 1006 - 2001 11704860
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth   highly
Lymphoid/Immunespleen   highly
Nervousbrainlimbic systemhippocampus highly Homo sapiens
 nervespinal nerve  highly
Respiratoryrespiratory tractlarynx  highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus
intracellular,nuclear envelope
basic FUNCTION
  • may play a role in regulating lymphocyte homeostasis
  • activating RhoA and involved in the control of neuronal cell differentiation
  • regulates RhoA signaling pathways in developing and mature forebrain neurons
  • recruited to junctions by members of the Crumbs polarity complex and promoted junction integrity by activating Diaphanous
  • importance of PLEKHG5 function in maintaining stable cell-cell contacts
  • RHOA-specific guanine nucleotide exchange factor PLEKHG5 is required for the polarity of actively migrating brain and breast tumor cells (PMID
  • recruitment of PLEKHG5 to the cell membrane and the subsequent selective activation of DIAPH1 signaling, coupled with the suppression of ROCK1 and activation of cofilin-mediated actin reorganization, plays a key role in establishing cell polarity during directed cell migration (PMID
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component AMOT forms a ternary complex together with INADL (or its paralogue MPDZ) and PLEKHG5
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts directly with the adapter TRADD
  • RND3 effector that interacts with RNDs via a RAF1-like Ras-binding domain
  • RND1, RND2, and RND3 stability is acutely dependent on interaction with their effectors such as PLEKHG5 or ARHGAP35
  • VEGFA caused translocation of PLEKHG5 from cell junctions, promoting junction disassembly, whereas ANGPT1 maintained PLEKHG5 at the junctions, inducing junction stabilization
  • binding of 14-3-3 proteins inhibits the GEF activity of PLEKHG5
  • may interact with a variety of partners including multiple PDZ domain protein 1 [MUPP1 or MPDZ)
  • function of PLEKHG5 is mediated by the selective activation of the RHOA downstream effector DIAPH1 (PMID
  • VEGFA induced interactions between NRP1 and GIPC1, a scaffold protein, and complex formation between GIPC1 and PLEKHG5, a RhoGEF
  • cell & other
    REGULATION
    repressed by RND3 (negatively regulates PLEKHG5, and that as a RhoA-GEF it plays a key role in early embryonic cell shape changes)
    ASSOCIATED DISORDERS
    corresponding disease(s) LMND2 , RICMTC
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • syx(-/-) mice had defective junctions, resulting in vascular leakiness, edema, and impaired heart function