basic FUNCTION
| cysteine proteinase in the ubiquitin pathway, cleaving proteins precisely at the ubiquitin -protein bond |
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with OTUB1, are negative regulators of virus-triggered type I IFN induction |
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negatively regulate virus-triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and TRAF6 |
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both OTUB1 and OTUB2 display a catalytic triad characteristic of proteases but differ in their configuration and protonation states |
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OTUB1, OTUB2 are potential therapeutic targets against aging-related disorders |
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by activating the AKT1 signaling pathway, OTUB2 and KRT80 facilitated Gastric cancer proliferation |