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FLASH GENE
Symbol OTUB2 contributors: mct - updated : 27-06-2022
HGNC name OTU domain, ubiquitin aldehyde binding 2
HGNC id 20351
DNA
TYPE functioning gene
STRUCTURE 22.55 kb     6 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3873 - 234 - 2004 15014966
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • OTU subfamily of deubiquitinylases.
  • peptidase C65 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • cysteine proteinase in the ubiquitin pathway, cleaving proteins precisely at the ubiquitin -protein bond
  • with OTUB1, are negative regulators of virus-triggered type I IFN induction
  • negatively regulate virus-triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 and TRAF6
  • both OTUB1 and OTUB2 display a catalytic triad characteristic of proteases but differ in their configuration and protonation states
  • OTUB1, OTUB2 are potential therapeutic targets against aging-related disorders
  • by activating the AKT1 signaling pathway, OTUB2 and KRT80 facilitated Gastric cancer proliferation
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    ubiquitin pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • OTUB1 and -2 interacted with TRAF3 and TRAF6, two E3 ubiquitin ligases required for virus-triggered IRF3 and NF-kappaB activation, respectively
  • OTUB2 is a regulator of GLI2 protein degradation
  • OTUB2 may have effect on osteogenic differentiation by regulating HH signaling
  • OTUB2 is an essential modulator of YAP/TAZ
  • OTUB2 may serve as a vital driver in Gastric cancer tumorigenesis by enhancing KDM1A-mediated stem cell-like properties
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • could be a novel prognostic marker in gastric cancer
  • Therapy target
    ANIMAL & CELL MODELS