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FLASH GENE
Symbol VIPAS39 contributors: mct - updated : 09-07-2015
HGNC name VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
HGNC id 20347
DNA
TYPE functioning gene
STRUCTURE 30.89 kb     21 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 2810 - 493 - 2009 19109425
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies ortholog to C. elegans spe-39
Homologene
FAMILY
  • SPE-39 family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • previously unrecognized regulator of lysosomal delivery
  • required for trafficking from early stages of the endocytic pathway (RAB11 and RAB5 compartments) toward lysosomes
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • HOPS (fusion and vacuole protein sorting) complexes
  • VIPAR forms a functional complex with VPS33B that interacts with RAB11A
  • VPS33B-VIPAR complex has diverse functions in the pathways regulating apical-basolateral polarity in the liver and kidney
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • VPS33B-interacting protein (VPS33B and VIPAS39 function as part of a complex that interacts with an active form of RAB11A involved in apical membrane protein sorting)
  • VIPAS39, with its partner proteins, regulate sorting of PLOD3 into newly identified post-Golgi collagen IV carriers and VIPAS39-dependent sorting is essential for modification of lysines in multiple collagen types
  • also interacts with VPS33 homologues and both coimmunoprecipitates and cosediments with other HOPS subunits
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ARCS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS