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FLASH GENE

Symbol

TRIM42

contributors: KTN/npt - updated : 02-02-2009

HGNC name	tripartite motif-containing 42
HGNC id	19014

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	23.11 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D3S3554 - D3S1316 - TRIM42 - D3S1309 - D3S3612 - qter
Authors	UCSC (2009)

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed TRIM42 5 - 2538 82.6 723 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal RING zinc finger
	two B box domains (one type 1 and one type 2), linked to a coiled-coil domain (RBCC) so called tripartite motif (TRIM)
	a COS (C-terminal subgroup one signature) domain
	an FN3 (fibronectin type 3) domain

HOMOLOGY

interspecies	homolog to rattus Trim42 (87.6 pc)
	homolog to murine Trim42 (87.1 pc)

Homologene

FAMILY	RBCC (TRIM family)
	C-III TRIM family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,nucleus

basic FUNCTION

identifying specific cell compartments

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS