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Symbol PPM1A contributors: mct - updated : 30-05-2015
HGNC name protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
HGNC id 9275
TYPE functioning gene
STRUCTURE 53.34 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
RBBP1 14q22.3 retinoblastoma binding protein 1 LOC387990 14 similar to TIMM9 TIMM9 14q22.3-q24 translocase of inner mitochondrial membrane 9 homolog (yeast) KIAA0586 14q23.1 KIAA0586 HSBP1P1 14 heat shock factor binding protein 1 pseudogene 1 HNRPCP 14 heterogeneous nuclear ribonucleoprotein C pseudogene DACT1 14q22.3 dapper homolog 1, antagonist of beta-catenin (xenopus) LOC387991 14 similar to ribosomal protein L31 LOC390482 14 similar to Aldo-keto reductase family 1, member B1 PPIAP5 14 peptidylprolyl isomerase A (cyclophilin A) pseudogene 5 DAAM1 14q22.3 dishevelled associated activator of morphogenesis 1 GPR135 14q23.1 G protein-coupled receptor 135 FLJ25436 14q23.1 hypothetical protein FLJ25436 C14orf100 14q22.3 chromosome 14 open reading frame 100 RTN1 14q21-q22 reticulon 1 FLJ46156 14q23.1 FLJ46156 protein C14orf135 14q23.1 chromosome 14 open reading frame 135 DHRS7 14q23.1 dehydrogenase/reductase (SDR family) member 7 PSMA3P 14 proteasome (prosome, macropain) subunit, alpha type, 3 pseudogene PPM1A 14q22.3-q23.1 protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform RBM8B 14q22.1-q22.3 RNA binding motif protein 8B pseudogene C14orf39 14q23.1 chromosome 14 open reading frame 39 LOC390483 14 similar to sal-like 4 SIX6 14q22.3-q23 sine oculis homeobox homolog 6 (Drosophila) LOC387992 14 LOC387992 SIX1 14q22-q23 sine oculis homeobox homolog 1 (Drosophila) SIX4 14q23 sine oculis homeobox homolog 4 (Drosophila) MNAT1 14q23 menage a trois 1 (CAK assembly factor) MAD2L1P 14 MAD2 mitotic arrest deficient-like 1 (yeast) pseudogene SRMP2 14 spermidine synthase pseudogene 2 SLC38A6 14q23.1 solute carrier family 38, member 6 LOC161291 14q23.1 hypothetical protein LOC161291 PRKCH 14q22-q23 protein kinase C, eta HIF1A 14q21-q24 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) SNAPC1 14q22 small nuclear RNA activating complex, polypeptide 1, 43kDa LOC122867 14q23.1 similar to cytochrome c oxidase subunit IV (COXIV) pseudogene (E.C. MOCS3P 14 molybdenum cofactor synthesis 3 pseudogene SYT14L 14q23.2 synaptotagmin XIV-like LOC390484 14 similar to ATP synthase alpha subunit
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 splicing 8210 42.3 382 - 2003 12514180
  • encoding the same isoform as the one encoded by variant 3
  • 6 exons
  • 4 splicing 4334 35.8 324 in brain 2003 12514180
  • 4 exons
  • containing an extra segment within the 5' UTR and having a different 3' region, which includes a part of the coding region as compared to variant 1
  • 6 splicing 8175 - 455 - 2003 12514180
  • 6 exons
  • differing in the 5' UTR compared to variant 1
  • encoding the same isoform than variant 1
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  predominantly
    Hearing/Equilibriumear   highly
    Lymphoid/Immunelymph node   moderately
    Nervousnerve   moderately
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone  moderately
    cell lineage
    cell lines
    at STAGE
    physiological period pregnancy
    Text placenta
  • a catalytic domain
  • secondary structure
  • a catalytic domain composed of a central beta sandwich that binds 2 manganese ions, which is surrounded by alpha helices
  • mono polymer monomer
    interspecies ortholog to rattus Ppm1a (99pc)
    ortholog to murine Ppm1a (98.2pc)
  • PP2C family of Ser/Thr protein phosphatases
  • metal-dependent serine/threonine protein phosphatase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • acting as a negative regulator of cell stress response pathways
  • negatively regulating the activities of MAP kinases and MAP kinase kinases
  • inhibiting the activation of p38 and JNK kinase cascades induced by environmental stresses
  • playing an important role in the regulation of receptors and channels
  • directly dephosphorylating Smad2 and Smad3 to limit their activation which plays a critical role in terminating TGFbeta signaling
  • involved in positive regulation of I-kappaB kinase/NF-kappaB cascade
  • inhibiting cell growth
  • activating the p53 pathway
  • might contribute to secretory cell function
  • PPM1A and PPM1B play an important role in the termination of TNF-mediated NF-kappaB activation through dephosphorylating and inactivating IKBKB
  • phosphatase which dephosphorylates and inactivates a broad range of substrates, including TGFB1, MAP kinases, MAPK14 and JNK kinase cascades, and is involved in tumor suppression
  • plays a critical role in the regulation of normal placentation by inhibiting trophoblast migration and invasion
  • critical role of PPM1A in maximizing exporter activity of RANBP3 for efficient termination of canonical TGFB1 signalling
  • plays a role in the differentiation and survival processes of nerve cells
  • might have an important role in oocyte maturation
  • represses HIV-1 gene expression by inhibiting CDK9 T-loop phosphorylation, thus reducing the amount of active CDK9 available for recruitment to the viral LTR
  • N-myristoylation of PPM1A and PPM1B plays a key role in recognition of their physiological substrates in cells
  • CELLULAR PROCESS cell cycle, progression
    cell life, proliferation/growth
  • involved in cell cycle control
    signaling signal transduction
    a component
    small molecule metal binding,
  • Mg2+ (2 ions per subunit)
  • Mn2+ (2 ions per subunit)
  • protein
  • GRM3 (C terminal cytoplasmic tail)
  • PPM1A and PPM1B, are IKBKB phosphatases
  • regulates the nuclear export of SMAD2/3 through targeting nuclear exporter RANBP3
  • directly interacted with and dephosphorylated RANBP3 at Ser 58
  • nuclear envelope-localized mechanism of inactivating TGFB1 signaling in which LEMD3 competes with transcription factors for binding to SMAD2 and SMAD3 and facilitates their dephosphorylation by PPM1A
  • cell & other
    Other N-myristoylated and this modification is essential for its ability to dephosphorylate the alpha subunit of AMPK in cells
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in hydatidiform moles compared with that during normal pregnancy
    Variant & Polymorphism
    Candidate gene
    Therapy target