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FLASH GENE
Symbol DHX32 contributors: mct - updated : 26-11-2020
HGNC name DEAH (Asp-Glu-Ala-His) box polypeptide 32
HGNC id 16717
DNA
TYPE functioning gene
STRUCTURE 44.96 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 3050 81 743 - 2017 28330603
lacking exon 4
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue   
Reproductivefemale systembreastmammary gland  
Respiratoryrespiratory tractlarynx   
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/H box (Asp - Glu - Ala - Asp/His)
  • terminal RNA helicase domain
  • HOMOLOGY
    interspecies ortholog to murine Dhx32
    Homologene
    FAMILY
  • DEAD/H box helicase family
  • DEAH subfamily
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • pre-mrna processing factor involved in disassembly of spliceosomes after the release of mature mRNA
  • DHX32 might play a role in normal lymphocyte differentiation
  • DHX32 might be involved in regulating T-cell response to certain apoptotic stimuli
  • may play an important role in the development of colorectal cancer
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text potentially involved in lymphopoiesis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule nucleotide,
    ATP
    protein
  • DHX32 in colorectal cancer cells upregulated expression VEGFA at the transcription level through interacting with and stabilizing CTNNB1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    acute lymphoblastic leukemia
    tumoral       gain of function
    in colorectal cancer (CRC) compared to its adjacent normal tissues
    Susceptibility
    Variant & Polymorphism
    Candidate gene for CORD17
    Marker
  • expression level of DHX32 has the potential to serve as a biomarker for colorectal cancer (CRC) diagnosis and prognosis
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    novel therapeutic target for colorectal cancer (CRC)
    ANIMAL & CELL MODELS