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FLASH GENE
Symbol INPP4B contributors: mct - updated : 14-04-2017
HGNC name inositol polyphosphate-4-phosphatase, type II, 105kDa
HGNC id 6075
DNA
TYPE functioning gene
STRUCTURE 818.42 kb     27 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text variants 1 and 2 encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 4140 105 924 - 2013 24070612
26 - 4041 105 924 - 2013 24070612
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   lowly
Nervousbrain   moderately
Respiratorylung   moderately
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • phosphatase domains are located within the C-terminus, with mostly alpha-helices
  • a CX5R (active site consensus sequence Cys-Xaa5-Arg) catalytic motif characteristic of dual-specificity phosphatases, such as PTEN
  • different AAs within the catalytic site of INPP4B are responsible for activity with lipid and protein substrates and for substrate specificity
    • HOMOLOGY
    interspecies ortholog to murine Inpp4b alpha
    homolog to rattus Inpp4b
    Homologene
    FAMILY
  • inositol-3,4-bisphosphate 4-phosphatase family
    • CATEGORY enzyme , tumor suppressor , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • removing the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate, 1,3,4-trisphosphate and phosphatidylinositol 3,4-bisphosphate
  • has potentially protein tyrosine phosphatase (PTP) activity 2)
  • major modulator of the osteoclast differentiation and as a gene linked to variability of bone mineral density
  • negative modulator of osteoclast differentiation
  • is an important regulator of phosphatidyl-inositol signaling in the cell
  • both PTEN and INPP4B are dual specificity phosphatases and tumor suppressors
  • regulates PI3K/Akt signaling and exerts a tumor suppressor effect, impacting the proliferative, invasive, and tumorigenic capacity of melanoma cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PTEN, INPP5J and INPP4B distinctly regulate PtdIns(3,4,5)P3 signalling downstream of PI3K and dysregulation of these phosphatases affects cancer outcomes
  • IRF2 binds INPP4B promoter and promotes INPP4B expression in Acute myeloid leukemia (AML) cells
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    associated with poor outcomes for breast, prostate, and ovarian cancer
    tumoral     --low  
    hyperactivation of the PI3K/AKT pathway caused by the decrease in INPP4B in granulosa cells promotes an ovarian environment defective in folliculogenesis and conducive to teratoma formation
    tumoral   LOH    
    in a majority of basal-like breast cancers, as well as in a significant fraction of ovarian cancers, which correlated with lower overall patient survival
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker prognostic locus for human osteoporosis
    Therapy target
    ANIMAL & CELL MODELS