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FLASH GENE

Symbol

HSF2

contributors: mct/npt - updated : 19-12-2018

HGNC name	heat shock transcription factor 2
HGNC id	5225

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	33.57 kb     13 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	cytosine-phosphate-guanine/HTF

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_004506 13 - 2697 NP_004497 - 536 - 2006 16600913 NM_001135564 12 - 2643 NP_001129036 - 518 - 2006 16600913 NM_001243094 7 - 1088 NP_001230023 - 230 - 2006 16600913

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Endocrine pancreas       highly Hearing/Equilibrium ear       highly Nervous brain       highly Reproductive male system prostate     highly Respiratory respiratory tract trachea     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HSF-type DNA binding domain

mono polymer

homomer , trimer

HOMOLOGY

interspecies

homolog to murine Hsf2

Homologene

FAMILY

HSF family

CATEGORY

DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	cytoplasmic during normal growth and nuclear upon activation

basic FUNCTION	participates in the transcriptional regulation of the heat shock response
	new role for HSF2 in the regulation of protein degradation
	playing an important role for constitutive as well as stress-inducible expression of HSE-containing genes
	plays roles in development of the brain and reproductive organs
	required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation
	role for HSF2 in the pathogenesis of Idiopathic azoospermia (IA)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

stress-responsive component of the stress granules

INTERACTION

DNA

RNA

small molecule

protein	SUMO1 (for the conversion of this factor to the active DNA binding form)
	interact with HSF1 through their trimerization domains (HSF1 influences the DNA binding activity of HSF2, and HSF2 influences to the localization of HSF1 in stress granules)
	interacting with PCGF2 (interaction with PCGF2 decreases during mitosis, resulting in elevated PCGF2 sumoylation)
	interaction between HSF2 and the APC/C subunit CDC27 and coactivator CDC20 is enhanced by moderate heat stress, and the degradation of HSF2 is induced during the acute phase of the heat shock response
	HSF2 and HSF4 regulate transcription of HIF1A and a critical balance between these HSF is required to maintain HIF1A expression in a repressed state
	HSF4 inhibits HSF2 expression or transcriptional activity through negative regulation of HSF2 binding to the HSP70 promoter
	HSF2 activated ALG3 and promoted the growth of breast carcinoma
	HSF2 could regulate aerobic glycolysis by suppression of FBP1 to support uncontrolled proliferation of hepatocellular carcinoma cells

cell & other

REGULATION

Other

regulated by SUMO1

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed reproduction fertility   potential therapeutic target for idiopathic azoospermia

ANIMAL & CELL MODELS