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FLASH GENE
Symbol COASY contributors: mct - updated : 21-01-2014
HGNC name Coenzyme A synthase
HGNC id 29932
DNA
TYPE functioning gene
STRUCTURE 4.82 kb     9 Exon(s)
regulatory sequence cytosine-phosphate-guanine/HTF
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2574 60 564 ubiquitous 2006 16460672
  • CoASy alpha
  • anchored to the outer mitochondrial membrane by the N-terminal region or localized within the mitochondrial matrix
  • 9 - 2182 60 564 ubiquitous 2006 16460672
  • CoASy alpha
  • anchored to the outer mitochondrial membrane by the N-terminal region or localized within the mitochondrial matrix
  • - - 2417 - 564 - 2006 16460672
    - - 1840 - 269 - 2006 16460672
  • COASY gamma
  • code potentially for C-terminal region of CoA synthase corresponding to DPCK domain
  • 11 - 2314 - 593 primarily expressed in the brain 2006 16460672
  • COASY beta
  • possesses a 29AA extension at the N-terminus
  • anchored to the outer mitochondrial membrane by the N-terminal region or localized within the mitochondrial matrix
  • possesses a proline-rich sequence which can bring the enzyme into complexes with signalling proteins containing SH3 or WW domains
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Endocrineadrenal gland   highly
    Lymphoid/Immunethymus   highly
    Nervousbrain    
    Reproductivefemale systemuterus   
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    Epithelialabsorptive excretorydigestive epithelium  
    Epithelialbarrier/liningepidermis  
    cells
    SystemCellPubmedSpeciesStageRna symbol
     fibroblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • phosphopantetheine adenylyltransferase
  • dephospho-CoA kinase domains (DPCK)
  • mono polymer heteromer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    basic FUNCTION
  • bifunctional enzyme catalyzing the fourth and fifth sequential steps of Coa biosynthetic pathway
  • having nucleotidyltransferase activity
  • bifunctional enzyme catalyzing the final steps of CoA biosynthesis by coupling phosphopantetheine with ATP to form dephospho-CoA and its subsequent phosphorylation to generate CoA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • COASY/EDC4 complex formation is regulated by growth factors and is affected by cellular stresses
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • involved in signaling events in the cell and forms a functional complex with PIK3R1
  • interacts with Src homology-2 (SH2) domains of a number of signaling proteins, including PTPN11
  • EDC4 interacts with and regulates the dephospho-CoA kinase activity of COASY
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NBIA6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS