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FLASH GENE

Symbol

OTOA

contributors: mct - updated : 10-10-2018

HGNC name	otoancorin
HGNC id	16378

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	98.49 kb     28 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144672 28 - 3624 NP_653273 126.7 1139 - 2012 23129639 NM_170664 19 - 2718 NP_733764 89.8 815 - 2012 23129639 NM_001161683 24 - 3480 NP_001155155 117.75 1060 - 2012 23129639

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Hearing/Equilibrium ear inner cochlea Corti   Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Hearing / Equilibrium cochlea cell

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text

cochlea

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative signal peptide
	conserved cysteine residues involved in higher order protein structure via disulfide bound formation
	eleven potential N glycosylation sites

HOMOLOGY

interspecies

homolog to murine Otoa

intraspecies

homolog to MPF

Homologene

FAMILY

stereocilin family

CATEGORY

adhesion

SUBCELLULAR LOCALIZATION	plasma membrane
text	interface between the apical surface of sensory cells and their overlaping acellular gels

basic FUNCTION	ensuring the attachment of the inner ear acellular gels to the apical surface of the underlying non sensory cells
	OTOA is required for adhesion of the tectorial membrane (TM) to the spiral limbus and the TM, despite the structural abnormalities, retains its gross overall form, remaining in close proximity with the organ of Corti

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

DFNB22

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

spontaneous otoacoustic emissions (SOAE) in mice lacking Otoa predominate around 7 kHz, which is much lower than in WT animals