basic FUNCTION
| transcriptional repressor playing an important role in the specification and differentiation of lung epithelium |
|
androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells |
|
crucial regulator of lung and esophageal development, underscoring the necessity of this transcription factor in the development of anterior foregut-derived tissues |
|
FOXP1 and FOXP2 may be involved in the determination of the cell type identities during late embryogenesis |
|
androgen-regulated gene, could be involved in the regulatory feedback loops for AR signaling |
|
essential transcriptional regulator for thymocyte development and the generation of quiescent naive T cells |
|
essential for the development of B cells, quiescent naive T cells and monocytes |
|
may play a role in the development of verbal and motor skill |
|
opposing transcriptional activities of FOXP1 and NFATC4 maintaining cardiomyocyte homeostasis |
|
critical roles for FOXP1 in the specification of cell lineages in early development |
|
FOXP1-regulated pathways might be important mediators of neuronal-glial cell communication |
|
is physiologically downregulated in germinal center B-cell and aberrant expression of FOXP1 impairs mechanisms triggered by B-cell activation, potentially contributing to B-cell lymphomagenesis |
|
represents an important modulator of FOXO-induced transcription, promoting cellular survival |
|
is crucial for maintaining the quiescence of hair follicle stem cells |
|
is essential for the angiogenic function of endothelial cells and functions as a suppressor of the inhibitory guidance cue SEMA5B, suggesting an important function of FOXP1 in the regulation of neovascularization |
|
is a critical negative regulator of CD4(+) follicular helper T cells (T(FH) cells) differentiation |
|
may play a central role in various cognitive and social processes |
|
IKZF1 and FOXP1 are transcription factors that play key roles in normal lymphopoiesis and lymphoid malignancies |