basic FUNCTION
| acting as an adaptor for the receptor ERBB2/HER2 |
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regulator of ERBB2/HER2 localization and signaling function |
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inhibits Ras-mediated activation of ERK in response to growth factors |
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may inhibit ERK activation by disrupting the SHOC2-Ras/Raf interaction |
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inhibit the Ras-mediated activation of the mitogen-activated protein kinase pathway |
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has the potential to act as an inhibitor as well as an activator of the beta-catenin-regulated gene expression |
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involved in the regulation of cell polarity |
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via the PDZ domain, binds to and stabilizes ERBB2, which is necessary for NRG1 signaling that has been implicated in tumorigenesis, heart development, and neural function |
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playing a critical role in myelination |
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negatively regulates the MAPK pathway downstream of tyrosine kinases including ERBB2 |
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ERBIN may function as a signaling molecule |
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interacting with MAGUK protein |
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negative regulator of the Ras-Raf pathway |
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unappreciated function of ERBIN in cell cycle progression |
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necessary role of ERBIN in remyelination of regenerating axons |
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participates in inhibition of several intracellular signaling pathways |
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is an inhibitor of pathological cardiac hypertrophy, and this inhibition is mediated, at least in part, by modulating ERK signaling |
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ERBIN is an ERBB2 regulator for breast tumor formation and progression |
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scaffold protein that regulates ERBB2 stability |
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ERBIN, LRRC1, and SCRIB act at the post-synaptic membrane of NMJs in a concerted fashion to regulate nicotinic acetylcholine receptors cluster morphology and neural transmission |