basic FUNCTION
| modulating the transport functions ascribed to SLC1A1 |
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playing an important role in regulating the metabolic function of SLC1A1 |
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involved in regulation of intracellular concentrations of taurine and glutamate |
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actively involved in the signal pathways of oxidative stress in the cells |
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may be involved in membrane trafficKing |
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signaling molecule, involved in the induction of differentiation of myeloid leukemia cells |
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regulator of ER protein trafficking |
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having the ability to regulate the trafficking of selected additional neuron-transmitter transporters and receptors |
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ARL6IP5-regulated-tumor cellular migration might involve MAPK cascades activation and F-actin cytoskeleton rearrangement mechanisms |
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having a unexpected role in tumor cell migration behaviors |
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glutamate transport-associated protein for SLC1A1, interacting with SLC1A1 at the plasma membrane and thereby regulating neuronal glutathione levels |
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dominantly and negatively determining the intracellular glutathione contents in neurons |
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regulator of ER protein trafficking |
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involved in cellular responses to environmental stress including oxidative stress |
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may serve as a novel regulator of XRCC1 in the BER (base excision repair) protein complex to facilitate the repair of DNA single-strand breaks |
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structurally novel microtubule-associated protein, which regulates cancer cell migration via MAPK cascades and mediates differentiation of leukemic cells |
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recruited by XRCC1 to the DNA damage sites, mediates the repair of DNA damage induced by oxidative stress via activating the expression of XRCC1 through MAPK-E2F1 signaling pathway and protecting XRCC1 from ubiquitin-proteasome degradation |
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directly involved in the regulation of chronic morphine dependence |
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ARL6IP5 in the ER controls intracellular TMEFF1 trafficking from the ER to plasma membrane and regulates cell migration through its interaction with TMEFF1 |
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has an important role in exocytic protein trafficking, glutathione metabolism and involves in cancer progression |
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function as an ER calcium regulator and control calmodulin signaling for osteoblast proliferation |
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is a novel regulator of bone formation in osteoblasts |
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plays pivotal roles in membrane traffic as a GDI displacement factor via physical interaction with a variety of Rab proteins |
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inhibits tumor progression by suppressing multiple oncogenes or activating tumor suppressor genes |