SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic,granule
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| text
| ubiquitous expressed  |
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can be translocated to the plasma membrane, where it may be involved in adhesion of granulocytes to endothelial cells |
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located in the membranes of lysosomes and dense granules |
| basic FUNCTION
| playing a role in the regulation of cell development, activation, growth and motility |
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plays a role in the regulation of KCNJ1 channels through its association with PTPRA, which in turn interacts with and activates Src family PTK, thus reducing KCNJ1 activity |
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may be involved in the integrin-dependent endocytosis and migration capacities of immature dendritic cells but also be able to modulate major histocompatibility complex class II transport to the cell |
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with CD9 ssociate with a type II phosphatidylinositol 4-kinase, PI4K55, in both resting and activated platelets |
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with CD9, CD63 and CD81 are all involved in CD9, CD63 and CD81 are all involved in MGC formation, but play distinct roles formation, but play distinct roles |
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function as organizer of multi-molecular signaling complexes involved in cell morphology, motility and proliferation |
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CD63 is thus a critical mediator of TRAF3 function in- and outside-infected (tumour) cells |
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marked differences in the signaling requirements for expression of ENPP3 and ITGAM versus CD63 expression and histamine release in human basophils |
