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FLASH GENE

Symbol

SERPINB2

contributors: mct - updated : 06-11-2013

HGNC name	serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
HGNC id	8584

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
SPECIAL FEATURE	component of a cluster
STRUCTURE	16.19 kb     8 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   silencer
text structure	a silencer PAUSE-1 in the promoter region, directing an active mechanism of transcriptional repression
	promoter is controlled by three major transcription regulatory domains: an inducible proximal promoter, an upstream silencer (PAUSE-1), and a distal transactivator region between -5100 and -3300, which appears to overcome inhibition mediated by the silencer
	promoter contains several AP-1 or AP-1-like consensus sequences, however, their presence does not automatically imply functionality in a given gene promoter

MAPPING

cloned

Y

linked

N

status

confirmed

Map	cen - D18S18 - SERPINB4 - [D18S38 - D18S60 - D18S51 /SERPINB2 - D18S68 - SERPINB5 - D18S42 - D18S14 - D18S55 ] - SERPINB3 - TGFBRE - D18S485 - D18S61 - qter
Authors	Schneider (95), LDB, Katz (99)
Text	[deletion in 18QDCR ]

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001143818 9 - 2180 NP_001137290 - 415 - 2013 2347408 NM_002575 8 - 1922 NP_002566 43 415 - 2013 2347408 secreted SERPINB2 was predominantly in its nonglycosylated 43kDa form

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive female system placenta       Skin/Tegument skin

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune macrophage

cell lineage
cell lines	tumor cell lines
fluid/secretion

at STAGE

physiological period

pregnancy

Text	placenta, trophoblasts

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

GlycoP

HOMOLOGY

Homologene

FAMILY

serpin family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	delivered to the plasma membrane, apparently together with TGOLN2 in the same vesicles, which after fusion with the membranes released cargo

basic FUNCTION	serine proteinase inhibitor
	plasminogen activator inhibitor type 2
	inhibit extracellular matrix degradation by PLAU (urokinase inhibitor)
	regulation of Th1 responses appears to be a physiological function of inflammation-associated SERPINB2
	enzyme inhibitor which is involved in various biological processes including cell differentiation, tissue regrowth and regeneration
	has a role for promoting the differentiation of epidermal keratinocytes
	in endothelial cells SERPINB2 induced with inflammatory stimuli, can inhibit proteasome and thus tilt the balance favoring proapoptotic signaling
	its extracellular concentration significantly increases during inflammation

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	protecting hematopoietic cells and keratinocytes from inappropriatly timed apoptosis

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	potent inhibitor of urokinase-type plasminogen activator (PLAU) and also acts as a multifunctional protein
	physiological interaction between RB1, RBL2 and SERPINB2
	is a cell survival factor that modulates RB1 repression of proapoptotic signal transduction
	while SERPINE1 and SERPINB2 function similarly in the control of cellular plasmin generation by PLAT, they may have disparate effects on the alternative functions of PLAT via modulation of its engagement with endocytosis receptors
	interacts with proteasome and affects its activity in endothelial cells
	SERPINB2 and TGM2 are downstream mediators in the antiapoptotic response triggered upon TBK1 activation
	FOSB is the mediator of SERPINB2 transactivator function explaining the orientation dependence observed for SERPINB2 transactivator activity
	FOSB and JUN can derepress transcription from the SERPINB2 promoter which may have general significance for SERPINB2-expressing cells
	extracellular matrix-associated proteins vitronectin and plasminogen activator inhibitor-2 (SERPINB2) were identified as novel CHL1 interaction partners, promoting CHL1-induced neurite outgrowth and neuronal migration

cell & other

REGULATION

induced by

high levels of expression after stimulation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in oral squamous cell carcinomas

Susceptibility

to myocardial infarction

Variant & Polymorphism SNP

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS