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FLASH GENE
Symbol PFKM contributors: mct/npt - updated : 22-09-2015
HGNC name phosphofructokinase, muscle
HGNC id 8877
DNA
TYPE functioning gene
STRUCTURE 26.86 kb     23 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
text structure at least two promoter regions
MAPPING cloned Y linked Y status provisional
Map pter - D12S345 - cen - D12S85 - PFKM - D12S361 - D12S347 - D12S368 - D12S390 - D12S96 - qter
Authors Howard (96)
regionally located previously assigned to chr 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
23 - 3234 85 780 - Yamada (2004)
- - 3536 - 851 - Yamada (2004)
- - 3088 - 780 - Yamada (2004)
- - 3177 - 780 - Yamada (2004)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveintestinesmall intestine   
Gustatory (taste)tongue   highly
Nervousbrain   highly
Reproductivemale systemtestis   
Respiratorylung    
Skin/Tegumentskin    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscular    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer tetramer
HOMOLOGY
Homologene
FAMILY
  • phosphofructokinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • rate-limiting enzyme in glycolysis
  • muscle isoform of phosphofructokinase (PFK), which phosphorylates fructose-6-phosphate to fructose-1,6-bisphosphate, commiting glucose to glycolysis (Garcia 2009)
  • glycolytic efficiency, which is important for the survival of cancer cells, depends primarily on the preferential expression of PFKL over the PFKM and PFKP isoforms
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism energetic , monocarbon
    signaling
  • fructose metabolism
  • energy pathway
  • glucose metabolism
  • glycogen metabolism
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
  • protein
    cell & other
    REGULATION
    activated by ADP
    AMP
    fructose bisphosphate
    inhibited by ATP
    citrate
    ASSOCIATED DISORDERS
    corresponding disease(s) GSD7
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Pfkm(-/-) mice had high lethality around weaning and reduced lifespan, because of the metabolic alterations (Garcia 2009)