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FLASH GENE
Symbol S100A7 contributors: mct - updated : 19-02-2018
HGNC name S100 calcium binding protein A7
HGNC id 10497
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 2.92 kb     3 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
Map pter - AMY@ - D1S73 - D1S11 - D1S189 - D1S252 - D1S13 - D1Z5 - cen - S100A7 - MUC1 - SPTA1 - FY - ATP1A2 - APOA2 APOA2 - qter
Authors Börglum (95)
Text see S100A@
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 450 11 101 - 2017 28976190
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 pharynx    
Reproductivemale systemtestis    Homo sapiens
Respiratoryrespiratory tractlarynx   
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatozoa Homo sapiens
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion amniotic, sperm
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one S100 specific Nter
  • two calcium binding domains
  • an EF-hand motif
  • central region, including only amino acids 35-80, is sufficient for full antibacterial activity
  • one zinc-binding motif, located at the C-terminus, involved in antibacterial activity
  • two EF-hand domains per subunit and two transition-metal-binding His3Asp sites at the dimer interface
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • S100 calcium binding protein family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text also secreted by a non-classical secretory pathway
    basic FUNCTION
  • acting as a potent and selective chemotactic inflammatory protein for CD4+ T lymphocytes
  • may be a marker of agressive behavior in invasive breast cancer
  • might play a role in the progression of skin cancer
  • may have consequential immunobiological effects during the fetal development
  • playing a role in modulating the immune response which may be a factor in early breast tumor progression (Mandal 2007)
  • enhances survival mechanisms in breast cells through an interaction with c-jun activation domain binding protein 1 (COPS5) (West 2009)
  • may mediate some of inflammatory cytokines effects in breast cancer (West 2010)
  • psoriasin is likely produced by the structures of the ocular surface and is part of the innate immune system at the ocular surface and tear film
  • an antimicrobial role seems likely for psoriasin in sperm
  • is a positive regulator of survival and invasion of prostate cancer cells
  • estrogen-induced S100A7 expression mediated by KDM1A may downregulate breast cancer cell proliferation, implying a potential tumor suppressor-like function for S100A7
  • psoriasin plays a role in the differentiation of luminal mammary epithelial cells
  • S100A7 and koebnerisin (S100A14) are released by keratinocytes during physiological wound healing
  • Psoriasin and koebnerisin show antifibrotic effects and may lead to novel preventive and therapeutic strategies for fibroproliferative diseases
  • functional role for AGER/S100A7 signaling in linking inflammation to aggressive breast cancer development
  • contributes likely to the dysregulated differentiation process in the psoriasis epidermis
  • metal-chelating protein expressed by epithelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • constituent of epidermal diffentiation complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
  • potential role of KDM1A in regulating S100A7 expression
  • S100A7 is repressed by YAP1 via the Hippo pathway
  • S100A7 induces mature IL1A expression in normal human epidermal keratinocytes, which is dependent on AGER/MAPK14 and calpain-1 as the inhibitors or knockdown of them completely decreased the expression of mature IL1A
  • cell & other
    REGULATION
    induced by OSM and IL6 in breast cancer (West 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the skin lesions of psoriasis, precancerous skin lesions, squamous cell carcinoma, basal cell carcinoma
    tumoral     --over  
    in breast cancer with poor prognosis (lobular carcinoma had higher levels compared with ductal tumours)
    tumoral     --over  
    in oral squamous cell carcinomas, and bladder cancer
    constitutional     --over  
    by keratinocytes surrounding the wound and is released into the wound exudat
    constitutional     --over  
    in psoriatic skin
    tumoral     --over  
    in high-grade ductal carcinoma in situ (DCIS) and a subset of invasive breast cancers
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • significant increase of salivary psoriasin was observed in Systemic sclerosis (SSc) patients with pulmonary involvement when compared with other healthy and pathological controls
  • potential role of S100A7 overexpression in identifying oral lesions (OLs) with dysplasia at high risk of cancer development
  • Therapy target
    ANIMAL & CELL MODELS