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FLASH GENE

Symbol

P2RX5

contributors: - updated : 21-07-2005

HGNC name	purinergic receptor P2X, ligand-gated ion channel, 5
HGNC id	8536

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.3      Physical location : 3.576.523 - 3.599.583
Synonym name	ionotropic ATP receptor 5
Synonym symbol(s)	P2X5, P2X5R

DNA

TYPE	functioning gene
STRUCTURE	23.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - - 2206 47 422 - Le variant 2 - splicing 2150 44 397 - Le lacking an in-frame segment of the coding region compared to variant 1 variant 3 - splicing 958 19 178 - Le lacking a segment in the coding region and differing in the 3' UTR compared to variant 1

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Lymphoid/Immune lymph node       moderately   spleen       moderately Nervous brain         Reproductive female system uterus cervix   predominantly Respiratory respiratory tract larynx     lowly

cell lineage
cell lines
fluid/secretion	blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

a transmembrane domain

conjugated

GlycoP

mono polymer

homomer , heteromer , polymer

HOMOLOGY

interspecies	ortholog to rattus P2rx5
	ortholog to murine P2rx5

Homologene

FAMILY	P2X receptor family
	family of purinoceptors for ATP

CATEGORY

receptor , transport channel

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	ionotropic ATP receptor 5
	receptor for ATP acting as a ligand gated ion channel

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

text	ion transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	ATP

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS