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FLASH GENE

Symbol

SLC5A4

contributors: mct/npt - updated : 30-03-2010

HGNC name	solute carrier family 5 (low affinity glucose cotransporter), member 4
HGNC id	11039

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q12.3      Physical location : 32.614.464 - 32.651.318
Synonym name	sodium/glucose cotransporter 3
	low affinity sodium glucose cotransporter
	solute carrier family 5 (neutral amino acid transporters, system A), member 4
Synonym symbol(s)	SAAT1, SGLT3, DJ90G24.4, SGLT2

DNA

TYPE	functioning gene
STRUCTURE	36.86 kb     15 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
text structure	transcriptional start site, located by primer extension analysis, was 391 bp upstream from the start codon (Inagi 2002)
	cis-acting element in the 5prime-flanking region of megsin involved in the activation of the megsin gene in mesangial cells (Inagi 2002)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014227 15 - 2029 NP_055042 - 659 - Fairchild (2008)

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive intestine small intestine         liver         Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid         Muscular

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	twelve transmembrane segments protein (12TM)
	cytoplasmic N and C termini

conjugated

GlycoP

HOMOLOGY

interspecies

ortholog to murine Slc5a4a

Homologene

FAMILY

sodium : solute symporter (SSF) family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

basic FUNCTION	acting as a sodium-dependent glucose transporter
	sodium ion transport
	sugar porter activity
	symporter activity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS