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FLASH GENE
Symbol INMT contributors: mlc/np - updated : 22-03-2004
HGNC name indolethylamine N-methyltransferase
HGNC id 6069
Location 7p15.3-p15.2      Physical location : 30.791.750 - 30.797.218
Synonym name
  • amine N-methyltransferase
  • nicotine N-methyltransferase
  • arylamine N-methyltransferase
  • thioester S-methyltransferase-like
  • Synonym symbol(s) MGC125940, MGC125941
    EC.number 2.1.1.49
    DNA
    TYPE functioning gene
    STRUCTURE 5.00 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2639 28 263 - Hillier (2003)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrinethyroid   highly
    Reproductivemale systemprostate  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    intraspecies homolog to indoleamines and beta carbolines,structurally
    Homologene
    FAMILY NNMT/PNMT/TEMT family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the N methylation of the tryptamine, serotonine and structurally related compounds
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS