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FLASH GENE
Symbol HIRIP3 contributors: npt/mct - updated : 10-01-2009
HGNC name HIRA interacting protein 3
HGNC id 4917
Location 16p11.2      Physical location : 30.004.310 - 30.007.412
DNA
TYPE functioning gene
SPECIAL FEATURE head to head
STRUCTURE 3.10 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 2352 62 556 - Assrir (2007)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Lymphoid/Immunespleen   highly
 thymus   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven N terminal WD-repeats
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    text nuclear throughout the cell cycle and excluded from condensed chromatin during mitosis
    basic FUNCTION
  • playing a role in chromatin assembly
  • member of the growing list of CSNK2A1 substrates with a possible role in chromatin metabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • H2B, H3 binding
  • binding directly to the WD-repeat protein HIRA
  • interacting with and phosphorylated by the serine-threonine kinase CSNK2A1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS