basic FUNCTION
| neutralizing the biological activity of activin (at least in pituitary) |
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inhibiting FSH in ovarian follicular fluid |
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potent tissue regulator in the gonad,pituitary glands, pregnancy membranes, vasculature and liver |
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exert critical autocrine or paracrine control in many tissues by binding and bio-neutralizing activin and several other transforming growth factor-beta ligands |
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mesenchymal factor that controls size, patterning and gustatory cell differentiation in developing taste papillae |
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normally acts to inhibit other TGFB family members in addition to myostatin to regulate muscle size |
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antagonist of activin and related TGFB superfamily members that has important reproductive actions as well as critical regulatory functions in other tissues and systems |
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regulates germ cell nest breakdown and primordial follicle formation |
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mediates muscle growth and bone mineralization |
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GDF11, ACTB and FST are crucial components of a circuit that controls both total cell number and the ratio of neuronal versus glial cells in in this system |
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possible involvement of a mechanism including follistatin in the uremic wasting process |
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is essential for skeletal muscle development and growth |
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is an autocrine protein with a heparin-binding motif that serves to regulate the cell proliferative activity of the paracrine hormone |
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single-chain glycosylated protein whose primary function consists in binding and neutralizing some members of the TGFB superfamily such as activin and bone morphogenic proteins |
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novel role of FST in the induction of brown adipocyte character and regulation of energy metabolism |
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important role of FST, a soluble glycoprotein that is known to bind and antagonize MSTN actions, during brown fat differentiation and the regulation of cellular metabolism |
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physiological inhibitor of MSTN, inducing a dramatic increase in skeletal muscle mass, requiring the type 1 IGFI receptor/AKT1/MTOR pathway |
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anabolic effects of FST are influenced by the interaction between muscle fibres and motor nerves |
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FST levels are associated with circulating leptin levels and display a day-night rhythm and a menstrual cycle |
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plays a role in tumourigenesis, metastasis and angiogenesis of solid tumours through its interaction with activin and BMPs, thus resulting in pathophysiological function |
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can induce ovarian arrest during pregnancy |