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FLASH GENE

Symbol

SLC13A2

contributors: mct - updated : 28-02-2014

HGNC name	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
HGNC id	10917

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.2      Physical location : 26.800.663 - 26.824.796
Synonym symbol(s)	NADC1, NaDC-1, CTR2

DNA

TYPE	functioning gene
STRUCTURE	23.00 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	pter - D17S2123 - [cen] - D17S841 - qter
Authors	Mann (99)
Text	[SLC13A2 ]

regionally located

between markers D17S2123 and D17S841

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 12 - 1952 - 592 - Okamoto (2007)

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine       Homo sapiens Respiratory respiratory tract trachea       Urinary kidney tubule convoluted tubule proximal tubule   Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Urinary tubular cell

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	at least eight transmembrane domains
	two potential protein kinase C phosphorylation sites, and two N-glycosylation sites

conjugated

GlycoP , PhosphoP

HOMOLOGY

interspecies	homolog to murine Slc13a2
	homolog to C.elegans f31f6.6

Homologene

FAMILY	NADC/P/Ph087 family of transporters
	NADC subfamily

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in osmoregulation
	reabsorbs Krebs cycle intermediates, such as succinate and citrate, from the glomerular filtrate
	involved in cotransport of sodium ions and dicarboxylates such as succinate and citrate
	SLC13A2 , SLC13A5 and SLC13A3, transport di- and tri-carboxylate Krebs cycle intermediates such as succinate, citrate and alpha-ketoglutarate
	primarily found on the apical membranes of renal proximal tubule and small intestinal cells, is involved in regulating urinary levels of citrate and plays a role in kidney stone development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

excretion , active transport

text	small molecule transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	metal binding,
	sodium Na+ (low affinity)

protein

cell & other

REGULATION

Other

acidic pH for citrate transport

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS