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FLASH GENE

Symbol

CD68

contributors: mlc - updated : 15-12-2007

HGNC name	CD68 antigen
HGNC id	1693

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17p13.1      Physical location : 7.482.804 - 7.485.428
Genatlas name	macrosialin
Synonym name	scavenger receptor class D member 1
	macrophage antigen CD68
Synonym symbol(s)	SCARD1, GP110, SCARD1

DNA

TYPE	functioning gene
STRUCTURE	2.00 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant A 6 - 1872 - 354 - O'Reilly (2007) variant B - - 1790 - 1872 - O'Reilly (2007)

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       highly Reproductive female system uterus cervix   highly   female system placenta     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic monocyte Lymphoid/Immune B cell Lymphoid/Immune macrophage Lymphoid/Immune T cell

cell lineage	cells of the mononuclear phagocytic lineage
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminal mucin-like domain
	9 potential N-glycosylation sites
	LAMP domain

conjugated

GlycoP

HOMOLOGY

interspecies

homolog to murineCd68

Homologene

FAMILY

member of the LAMP macrosialin family of hemapoietic mucin-like molecules

CATEGORY

antigen

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome
text	type 1 membrane protein
	expressed within the endosomal compartment of the cell and rapidly shuttles to the plasma membrane where it is postulated to participate in cell adhesion and antigen presentation

basic FUNCTION	macrophage-specific gene, participating in cell adhesion and antigen presentation
	may also bind oxidized low-density lipoproteins and may contribute to the development of macrophage foam cells in atherosclerotic plaques

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

Other

regulated at multiple levels, which are inextricably interconnected

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS