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FLASH GENE
Symbol RNASE1 contributors: - updated : 14-03-2007
HGNC name ribonuclease, RNase A family, 1 (pancreatic)
HGNC id 10044
Location 14q11      Physical location : 21.269.515 - 21.271.036
Synonym name RNase upI-1
Synonym symbol(s) HPRNASE, MGC12408, RIB1, RNS1, HPR
EC.number 3.1.27.5
DNA
TYPE functioning gene
STRUCTURE 1.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - 827 - 156 - Wang
- - 907 - 156 - Wang
- - 898 - 156 - Wang
- - 889 - 156 - Wang
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
 stomach   highly
Endocrineadrenal gland   highly
 pancreas    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
eight cysteine and histidine and lysine residues
HOMOLOGY
Homologene
FAMILY ribonuclease,RNAse A family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION extracellular
basic FUNCTION involved in vascular homeostasis
CELLULAR PROCESS
PHYSIOLOGICAL PROCESS
PATHWAY
metabolism
signaling
a component
INTERACTION
DNA
RNA
small molecule
protein
  • interact very strongly with the intracellular ribonuclease inhibitor (RI)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS