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FLASH GENE

Symbol

LAIR1

contributors: mct - updated : 14-03-2012

HGNC name	leukocyte-associated Ig-like receptor 1
HGNC id	6477

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19q13.42      Physical location : 54.865.234 - 54.876.721
Synonym symbol(s)	LAIR-1, 9.1C3, XXbac-BCX403H19.4, CD305, LAIR-1

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
STRUCTURE	11.49 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Map	see FLNKR@

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002287 10 - 2816 NP_002278 32 287 - 1997 9285412 LAIR1-a NM_021706 9 splicing 2765 NP_068352 - 270 - 1997 9285412 LAIR1-b LAIR1-c - splicing 810 - 269 - 1997 9285412 LAIR1-d - splicing 950 - 209 - 1997 9285412

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Blood/Hematopoietic monocyte Lymphoid/Immune dendritic cell Homo sapiens Lymphoid/Immune T cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo

Text	hematopoietic progenitor

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a single Ig-like domain
	a cytoplasmic tail
	two immunoreceptor tyrosine-based inhibitory motifs (ITIM) in its cytoplasmic region
	a collagen-binding domain, homologous to that of glycoprotein VI (GPVI), a collagen receptor crucial for platelet activation

HOMOLOGY

intraspecies

homolog to LAIR2

Homologene

FAMILY

immunoglobulin (Ig) superfamily

CATEGORY

immunity/defense , signaling , receptor

SUBCELLULAR LOCALIZATION	plasma membrane
text	type 1 membrane protein

basic FUNCTION	hematopoietic cell signaling, may be implicated in regulating hematopoiesis at early stage
	negative regulator of natural killer (NK) cells
	can function independently from SH2 domain-containing phosphatases and must recruit at least one other signaling molecule
	regulated expression of LAIR1 and the subsequent change in the threshold for activation may be a mechanism to modulate inhibition of the immune system
	receptor that potentially is able to regulate multiple steps of an immune response
	collagen-receptor that inhibits immune cell function upon collagen binding
	most widely spread immune receptors, attenuating immune cell activation when bound to specific sites in collagen
	inhibitory function of LAIR1 may play a relevant role in the mechanisms controlling IFNA production by Plasmacytoid dendritic cells both in normal and pathological innate immune responses
	inhibitory collagen receptor, that serves as a negative regulator of megakaryocytopoiesis
	plays a role in regulating immune cells, suggesting that any adverse effects of its absence may be balanced in vivo by other inhibitory receptors

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	PTPN6
	phosphorylated LAIR1 bound the C-terminal SRC kinase (CSK) (interaction required the SH2 domain of CSK and phosphorylation of the tyrosine in the N-terminal ITIM of LAIR1)
	LAIR2 may function as a natural competitor for LAIR1, thereby regulating its inhibitory potential
	collagens act as ligands for the inhibitory receptor LAIR1, which inhibits the function of multiple types of immune cells

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS