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FLASH GENE

Symbol

MAP2K3

contributors: mct/npt - updated : 06-02-2008

HGNC name	mitogen-activated protein kinase kinase 3
HGNC id	6843

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q11.2      Physical location : 21.187.967 - 21.218.549
Synonym name	MAP kinase kinase 3
	MAPK/ERK kinase 3
	dual specificity mitogen activated protein kinase kinase 3
Synonym symbol(s)	MEK3, MKK3, PRKMK3, MAPKK3, SAPKK2
EC.number	2.7.1.37/ 2.7.12.2

DNA

TYPE	functioning gene
STRUCTURE	30.58 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant a 14 - 2304 isoform a - 318 - Derijard, Raingeaud (1996) variant c - splicing 2160 isoform c - 352 - Han variant b 12 splicing 2319 isoform b - 347 - Han, Raingeaud (1996)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	serine-threonine protein kinases, catalytic domain
	a docking site, a stretch of about 20 amino acids immediately on the C-terminal side of the MAPKK catalytic domain (Takekawa 2005)

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Map2k3
	homolog to C.elegans R03g5.2

intraspecies

homolog to MAP2K6

Homologene

FAMILY	protein kinase superfamily
	STE Ser/Thr protein kinase family
	MAP kinase kinase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

basic FUNCTION	serine/threonine kinase controling cell proliferation
	regulating MAPK14 in fibroblast-like synoviocytes (Inoue 2005)
	have differential roles in osteoclastogenesis as MAP2K6 from bone marrow precursors (Huang 2006)

CELLULAR PROCESS	cell life, proliferation/growth

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

phosphorylation

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   deletion     homozygously, in lung cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS