protein
| SH3KBP1-interacting partner (enhances the activation of MKK6 and of the downstream MAPK14 following oxidative stress and growth factor stimulation) |
|
FLNA, impacts neuronal migration initiation and provides insight into the pathogenesis of periventricular heterotopia |
|
link between MAPK signalling in proliferating gonadal somatic cells and regulation of SRY expression (Bogani 2009) |
|
interacts with TRAF4 (MAP3K4 is the MAPK kinase kinase for TRAF4 regulation of the JNK pathway) (Abell 2005) |
|
MAP3K4 controls the activity of the histone acetyltransferase CREBBP, and acetylation of histones H2A and H2B by CREBBP is required to maintain the epithelial phenotype |
|
spatial regulation of MAPK14 by GADD45B/MAP3K4 negatively regulates the autophagic process |
|
interaction of SH3KBP1 with MAP3K4 was increased during the late phase of TNFSF10 incubation, suggesting that sustained MAPK14 and HSPB1 phosphorylation protects cells by preventing further cell death |
|
MAP3K4 and MAP3K10 are sufficient for mediating the TGFB1-induced activation of MAPK14 |
|
MAP3K4 acts as a critical node to integrate FGF20-FGFR1 signaling responses to specifically influence hair cells (HCs) development |
|
GADD45A interacts with multiple proteins in skeletal muscle fibers, including, most prominently, MAP3K4, a mitogen-activated protein kinase kinase kinase that was not previously known to play a role in skeletal muscle atrophy |
|
MAP3K4 activity controls epithelial-to-mesenchymal transition (EMT) through the ubiquitination and degradation of HDAC6 |