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FLASH GENE
Symbol ZNF420 contributors: mct/pgu - updated : 02-03-2011
HGNC name zinc finger protein 420
HGNC id 20649
Location 19q13.12      Physical location : 37.569.381 - 37.620.649
Synonym name ATM and p53-associated KZNF protein
Synonym symbol(s) APAK, FLJ32191, BC026210, KZNF
DNA
TYPE functioning gene
STRUCTURE 51.27 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2990 80.1 688 - 2009 19377469
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal KRAB domain
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    text localized predominantly in the nucleoplasm and less to the nucleolus
    basic FUNCTION
  • specifically downregulates pro-apoptotic genes, and suppresses p53-mediated apoptosis by recruiting KRAB-box-associated protein TRIM28 and histone deacetylase 1 (HDAC1) to attenuate the acetylation of TP53
  • ATM and TP53-associated ZNF420 are negative regulator of TP53-mediated apoptosis
  • specifically suppresses TP53-mediated apoptosis
  • interacts directly with TP53 through its zinc-fingers and recruits KRAB-box-associated protein-1 (TRIM28) and histone deacetylase 1 (HDAC1) to attenuate the acetylation of TP53 through its N-terminal KRAB domain
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • ions Zn2+
  • protein
  • binds directly to TP53 in unstressed cells
  • ZNF-TP53 interaction is regulated differentially by various DNA damage signals
  • inhibitory function of ZNF420 requires the cooperation of ATM kinase
  • CDKN2A-ZNF420 interaction could be induced or enhanced in response to oncogene activation
  • negatively regulated in response to DNA damage and oncogene activation in the ATM- and CDKN2A-dependent manner, respectively
  • cell & other
    REGULATION
    inhibited by in the tumor suppressor ARF-dependent but ATM-independent manner
    Other phosphorylated by ATM
    phosphorylated and inhibited by ATM kinase, resulting in TP53 activation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS