basic FUNCTION
| plays an essential role in ER Ca2+ handling and is also implicated in signaling from the ER, which is closely associated with cell-fate decision |
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high capacity Ca2+ binding protein on the ER, which acts as a sensor of Ca2+ concentration within the ER lumen |
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ER Ca2+ binding protein calumin is associated with CRAC channels and and modulates their activity by decreasing the Ca2+ selectivity of the channel |
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calumin serves likely to maintain the yolk sac integrity through participation in the ERAD activity, contributing to embryonic development |
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is a unique calcium regulating protein that is associated with early onset hypertrophic cardiomyopathy |
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is critical for Ca2+ signaling and normal development |
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is important for the maintenance of Ca2+ homeostasis and signaling in the ER |