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FLASH GENE

Symbol

ANKRD54

contributors: mct/npt - updated : 08-06-2017

HGNC name	ankyrin repeat domain 54
HGNC id	25185

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.1      Physical location : 38.226.862 - 38.240.353
Synonym name	Lyn-interacting ankyrin repeat
Synonym symbol(s)	LIAR

DNA

TYPE	functioning gene
STRUCTURE	18.14 kb     8 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_138797 8 - 2099 NP_620152 32 300 - 2012 22527282 NM_001349853 - - 2770 NP_001336782 - 235 - 2012 22527282

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine neuroendocrine pituitary       Lymphoid/Immune tonsils         Reproductive female system uterus cervix   highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	functional nuclear localization and nuclear export sequences
	3 of the ankyrin repeats define a novel SH3 binding region for LYN and HCLS1 (Samuels 2009)

HOMOLOGY

Homologene

FAMILY

ankyrin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus
text	shuttles rapidly between the nucleus and cytoplasm (Samuels 2009)

basic FUNCTION	is a novel LYN-interacting molecule that plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation (Samuels 2009)
	is the first protein identified that specifically influences the nucleocytoplasmic shuttling of BTK and TXK and belongs to a rare group of known proteins carrying out this activity in a CRM1-dependent manner

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

forms a multiprotein complex with LYN and HCLS1 in erythroid cells (Samuels 2009)

INTERACTION

DNA

RNA

small molecule

protein

nucleocytoplasmic shuttling of BTK is specifically modulated by the Ankyrin Repeat Domain 54 (ANKRD54) protein and the interaction is known to be exclusively SH3-dependent

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS