basic FUNCTION
| involved in the early steps in the assembly of the 3'end processing complex |
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is a unconventional Nudix protein |
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controls cell fate by connecting alternative polyadenylation to chromatin signaling |
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NUDT21 inhibits hepatocellular carcinoma proliferation, metastasis and tumorigenesis, at least in part, by suppressing PSMB2 and CXXC5 |
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is required for 3'RNA cleavage and polyadenylation |
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NUDT21 and serine/arginine-like protein CPSF6, regulates alternative polyadenylation (APA) |
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is a crucial mediator involved in alternative polyadenylation (APA), and has been reported to be a tumor suppressor in human cancers |
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NUDT21 plays a crucial role in bladder cancer progression, at least in part through ANXA2 and LIMK2 which act by alternative polyadenylation |