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FLASH GENE
Symbol NUDT21 contributors: mct - updated : 03-03-2020
HGNC name nudix (nucleoside diphosphate linked moiety X)-type motif 21
HGNC id 13870
Location 16q13      Physical location : 56.463.048 - 56.485.261
Synonym name
  • cleavage and polyadenylation specific factor 5
  • CPSF25
  • Synonym symbol(s) CPSF5, CFIM25, DKZp686H1588, CPSF25
    DNA
    TYPE functioning gene
    STRUCTURE 22.20 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 4393 - 227 - 2019 30705404
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N&
  • 8208;terminal stretch (residues &
    8764;22–28) makes extensive interactions with one surface of the CPSF5 subunit, mainly composed by beta2 and beta9
  • one nudix (Nudt/mutT) domain, a Nudix sequence motif characteristic of Nudix family hydrolases
  • HOMOLOGY
    Homologene
    FAMILY nudix family
    CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text paraspeckles
    basic FUNCTION
  • involved in the early steps in the assembly of the 3'end processing complex
  • is a unconventional Nudix protein
  • controls cell fate by connecting alternative polyadenylation to chromatin signaling
  • NUDT21 inhibits hepatocellular carcinoma proliferation, metastasis and tumorigenesis, at least in part, by suppressing PSMB2 and CXXC5
  • is required for 3'RNA cleavage and polyadenylation
  • NUDT21 and serine/arginine-like protein CPSF6, regulates alternative polyadenylation (APA)
  • is a crucial mediator involved in alternative polyadenylation (APA), and has been reported to be a tumor suppressor in human cancers
  • NUDT21 plays a crucial role in bladder cancer progression, at least in part through ANXA2 and LIMK2 which act by alternative polyadenylation
  • CELLULAR PROCESS nucleotide, RNA splicing
    PHYSIOLOGICAL PROCESS
    text RNA cleavage and polyadenylation processing
    PATHWAY
    metabolism
    signaling
    a component component of the cleavage factor with CFIM68 (CPSF6)and other peptides
    INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein
  • elevated NUDT21 increases usage of the distal polyadenylation site in the MECP2 3' UTR, resulting in an enrichment of inefficiently translated long mRNA isoforms
  • PAK1 expression is regulated by NUDT21 through its 3'-UTR alternative polyadenylation (APA)
  • interaction between NUDT21 and EZH2 may play an important role in the crosstalk between alternative polyadenylation (APA) and miRNA-mediated gene silencing in Preeclampsia
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • NUDT21 and its downstream target PAK1 is a potential "combination biomarker" for predicting prognosis of glioblastoma patients
  • Therapy target
    SystemTypeDisorderPubmed
    cancerurinary 
    therapeutic target in treatment of Bladder cancer
    ANIMAL & CELL MODELS