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FLASH GENE
Symbol LIMD2 contributors: mct - updated : 27-03-2023
HGNC name LIM domain containing 2
HGNC id 28142
Location 17q23.3      Physical location : 61.773.249 - 61.777.519
Synonym name
  • testicular tissue protein Li 106
    • Synonym symbol(s) MGC10986
    DNA
    TYPE functioning gene
    STRUCTURE 5.27 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 3192 - 127 - 2021 34724866
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • LIMD2 is a new component of the signal transduction cascade that links integrin-mediated signaling to cell motility/metastatic behavior
  • is a small LIM-only protein that has been demonstrated to promote tumor progression
  • LIMD2 enhances phosphorylation of kinases associated with EMT and invasion
  • LIMD2 promotes the proliferation and invasion of ovarian cancer, potentially through regulating the focal adhesion signaling pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Ovarian cancer (OC)
    tumoral     --over  
    in non-small cell lung cancer (NSCLC), significantly associated with lymph node metastasis, distant metastasis and advanced clinical stage
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerlung 
    may be used as a potential therapeutic target for the treatment of NSCLC.
    ANIMAL & CELL MODELS