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FLASH GENE

Symbol

HES2

contributors: mct - updated : 03-12-2010

HGNC name	hairy and enhancer of split 2 (Drosophila)
HGNC id	16005

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.31      Physical location : 6.475.294 - 6.479.979
Synonym name	transcription factor HES-2
	hairy and enhancer of split homolog 2
	class B basic helix-loop-helix protein 40
Synonym symbol(s)	FLJ33803, bHLHb40

DNA

TYPE	functioning gene
STRUCTURE	4.69 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_019089 4 - 4273 NP_061962 - 173 - 2004 15254753

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue       Reproductive female system placenta         female system uterus cervix     Respiratory respiratory tract trachea

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	an N-terminal basic helix-loop-helix domain
	an orange domain
	a proline-rich domain
	a C-terminal WRPW motif

HOMOLOGY

Homologene

FAMILY

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	repressor of genes that require a bHLH protein for their transcription
	at later stages of development, promote gliogenesis
	play an essential role in neural development by regulating proliferation, differentiation and specification of neural stem cells

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         expressed in pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS