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FLASH GENE
Symbol CYB5B contributors: mct - updated : 03-09-2010
HGNC name cytochrome b5 type B (outer mitochondrial membrane)
HGNC id 24374
Location 16q22.1      Physical location : 69.458.497 - 69.500.167
Synonym name
  • outer mitochondrial membrane cytochrome b5
  • cytochrome b5 outer mitochondrial membrane isoform
    • Synonym symbol(s) CYB5-M, OMB5, DKFZp686M0619, CYB5M, CYPB5M
    DNA
    TYPE functioning gene
    STRUCTURE 41.67 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4286 21 150 - Soucy (2002)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • cytochrome b5 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • microsomal cytochrome b5 can play a major role in the metabolism of certain drugs and chemicals but in a P450- and substrate-dependent manner (Finn 2008)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • between visinin-like protein-3 and microsomal cytochrome B5 (Oikawa 2004)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in Hodgkin Lymphoma (HL) and aggressive Non-Hodgkin Lymphomas (NHL) (Murphy 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS