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FLASH GENE
Symbol ALKBH3 contributors: mct/npt - updated : 26-06-2019
HGNC name alkB, alkylation repair homolog 3 (E. coli)
HGNC id 30141
Location 11p11.2      Physical location : 43.902.356 - 43.941.825
Synonym name
  • prostate cancer antigen-1
  • alkylated repair protein alkB homolog 3
  • alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
  • prostate cancer antigen 1
    • Synonym symbol(s) ABH3, DEPC-1, DEPC1, MGC118790, MGC118792, MGC118793, PCA1
    EC.number 1.14.11.-
    DNA
    TYPE functioning gene
    STRUCTURE 39.00 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 1519 33.4 286 - Sundheim (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systemovary  moderately
     male systemprostate  moderately
     male systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Alkbh31
    Homologene
    FAMILY
  • Fe(II)/2OG-dependent dioxygenase superfamily
  • ALKB family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text in nuclei and cytoplasm
    basic FUNCTION
  • having DNA demethylase activity
  • removing 1-methyladenine and 3-methylcytosine from methylated polynucleotides in an alpha-ketoglutarate-dependent reaction, and act by direct damage reversal with the regeneration of the unsubstituted bases
  • couples substrate oxidation to conversion of 2-oxoglutarate into succinate and CO2
  • ALKBH2-3 and ALKBH7 correct methyl and etheno adducts in DNA
    • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Fe(2+) ion per subunit
    • protein
    cell & other
    REGULATION
    activated by ascorbate
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS