basic FUNCTION
| promoting malignant B-cell migration |
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transcription modulator that is overexpressed in chemoresistant, diffuse large B-cell lymphomas |
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having an active role in sperm cell physiology in preventing apoptosis |
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with PARP14, are macro domain containing poly(ADP-ribose) polymerases involved in transcriptional regulation in response to immunoregulatory cytokines |
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DTX3L and PARP9 are bona fide members of a DNA damage response pathway and are directly associated with PARP1 activation, BRCA1 recruitment, and double-strand break repair |
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may induce an switch in STAT1 from a tumor suppressor to an oncogene in high-risk Diffuse large B cell lymphoma (DLBCL) |
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DTX3L and PARP9 act together as repressors of the tumor suppressor IRF1 in prostate cancer cells |