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FLASH GENE
Symbol PARP9 contributors: mct/npt/pgu - updated : 11-07-2015
HGNC name poly (ADP-ribose) polymerase family, member 9
HGNC id 24118
Location 3q21.1      Physical location : 122.246.761 - 122.283.523
Synonym name
  • B-aggressive lymphoma-1 protein
  • Synonym symbol(s) BAL, BAL1, MGC:7868, DKFZp666B0810, DKFZp686M15238, FLJ26637, FLJ35310, FLJ41418, FLJ43593, ARTD9
    EC.number 2.4.2.30
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head
    text located on chromosome 3q21 in a head-to-head orientation with DTX3L
    STRUCTURE 36.65 kb     11 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3177 - 854 - 2006 16809771
    - - 3254 - 819 - 2006 16809771
    11 - 3359 - 854 - 2006 16809771
    - - 3253 - 819 - 2006 16809771
    - - 3072 - 819 - 2006 16809771
    - - 6801 - 710 - 2006 16809771
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
     mouthtongue  highly
    Lymphoid/Immunespleen   highly
    Reproductivefemale systembreastmammary gland highly
    cell lineage
    cell lines DLB-CL cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • duplicated N-terminal domain homologous to the nonhistone portion of histone-macroH2A
  • a C-terminal alpha-helical region with 2 short coiled-coil domains
  • HOMOLOGY
    Homologene
    FAMILY
  • PARP family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • promoting malignant B-cell migration
  • transcription modulator that is overexpressed in chemoresistant, diffuse large B-cell lymphomas
  • having an active role in sperm cell physiology in preventing apoptosis
  • with PARP14, are macro domain containing poly(ADP-ribose) polymerases involved in transcriptional regulation in response to immunoregulatory cytokines
  • DTX3L and PARP9 are bona fide members of a DNA damage response pathway and are directly associated with PARP1 activation, BRCA1 recruitment, and double-strand break repair
  • may induce an switch in STAT1 from a tumor suppressor to an oncogene in high-risk Diffuse large B cell lymphoma (DLBCL)
  • DTX3L and PARP9 act together as repressors of the tumor suppressor IRF1 in prostate cancer cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexes with a recently described DELTEX family member DTX3L
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • physically interacts with both STAT1A and STAT1B through its macrodomains in an ADP-ribosylation-dependent manner, and directly inhibits, together with STAT1B, the expression of tumor suppressor and interferon response factor IRF1
  • cell & other
    REGULATION
    Other regulated by a IFN-gamma-responsive bidirectional promoter
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    diffuse large B-cell lymphomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS