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FLASH GENE
Symbol RASA4 contributors: - updated : 03-10-2007
HGNC name RAS p21 protein activator 4
HGNC id 23181
Location 7q22      Physical location : 102.220.093 - 102.257.205
Synonym name
  • Ca2+-promoted Ras inactivator
  • GTPase activating protein-like
  • calcium-promoted Ras inactivator
  • Synonym symbol(s) GAPL, CAPRI, KIAA0538
    DNA
    TYPE functioning gene
    STRUCTURE 37.00 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 5626 - 803 - Liu
    - - 5488 - 757 - Liu
    - - - - - in primary osteoblasts Hikita
  • possible regulator of TNFSF11 shedding (would promote the TNFSF11shedding through up-regulation of MMP14)
  • lacks part of the RasGAP domain
  • activates the Ras pathways, which increase the expression of MMP14 in a Mek/Erk-independent manner and lead to the TNFSF11 shedding
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   predominantly
     thymus   moderately
    Reproductivefemale systemuteruscervix highly
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousperipherous   
    cell lineage
    cell lines
  • jurkat cell line/T cell
  • fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BTK domain
  • an amino-terminal tandem C2 domain
  • a GAP-related domain/ras-gap domain
  • a carboxy-terminal pleckstrin homology domain
  • HOMOLOGY
    Homologene
    FAMILY member of the GAP1 family of Ras GTPase-activating proteins (GAPs)
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text elevation of the intracellular Ca2+ causes a rapid C2 domain-dependent translocation to the plasma membrane, resulting in the activation of the RasGAP activity and the inactivation of the Ras/Mek/Erk pathways
    basic FUNCTION
  • playing a probable role as inhibitory regulator of the ras-cyclic amp pathway
  • Ca(2+)-dependent Ras GTPase-activating protein, switching off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium
  • suppressing RANKL shedding promoted by delta-CAPRI
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • intracellular signaling cascade
  • ras-cyclic amp pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
  • utilizing the C2A and C2B domains to associate with the plasma membrane
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS