Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol EXOSC8 contributors: mct - updated : 07-06-2018
HGNC name exosome component 8
HGNC id 17035
Corresponding disease
PCH1C pontocerebellar hypoplasia, type 1C
Location 13q13.3      Physical location : 37.574.677 - 37.583.749
Synonym name Opa-interacting protein 2
Synonym symbol(s) p9, CIP3, EAP2, OIP2, RRP43, Rrp43p, bA421P11.3, PCH1C
EC.number 3.1.13.-
DNA
TYPE functioning gene
STRUCTURE 8.00 kb     11 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1427 - 276 - 2002 11929972
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer complex
HOMOLOGY
interspecies homolog to murine EXOSC8
homolog to rattus LOC295050
homolog to yeast Rrp43
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
intracellular,nucleus,nucleolus
basic FUNCTION
  • have 3'->5' exoribonuclease activity
  • processes the 3' terminus of precursor tRNA
  • required for rapid degradation of ARE-containing RNA
  • is an essential protein of the exosome core
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component exosome C RNase complex
    INTERACTION
    DNA
    RNA RNA binding
    small molecule
    protein
  • interacts with RPP14
  • GATA1/FOXO3 repressed expression of EXOSC8, a pivotal component of the exosome complex, which mediates RNA surveillance and epigenetic regulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCH1C
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    downregulating EXOSC8, or additional exosome complex components, in primary erythroid precursor cells induced erythroid cell maturation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS