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FLASH GENE

Symbol

RGMA

contributors: mct/ - updated : 07-06-2006

HGNC name	RGM domain family, member A
HGNC id	30308

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q26.1      Physical location : 93.586.636 - 93.632.443
Synonym name	repulsive guidance molecule A

DNA

TYPE	functioning gene
STRUCTURE	45.80 kb     4 Exon(s)    1 Copie(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

linked

status

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001166283 - - 3200 NP_001159755 50 458 - - variant 1/isoform 1 NM_001166286 - - 3060 NP_001159758 47.4 434 - - variant 2/isoform 2 NM_001166287 - - 3174 NP_001159759 47.4 434 - - variant 3/isoform 2 NM_001166288 - - 3058 NP_001159760 47.4 434 - - variant 5/isoform 2 NM_001166289 - - 3078 NP_001159761 47.4 434 - - variant 6/isoform 2 NM_020211 4 - 3227 NP_064596 49.2 450 - - variant 4/isoform 3

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly Nervous brain midbrain       Reproductive female system ovary     highly   male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal   highly

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	optic tectum of the midbrain

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	GPI anchored glycoprotein
	a N terminal RGM domain
	a C terminal RGM domain

HOMOLOGY

Homologene

FAMILY

repulsive guidance molecule (RGM) family

CATEGORY

signaling , receptor nuclear

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	repulsive and specific guiding activity in the optic tectum
	RGM/neogenin regulates cell fate by controlling the DAPK1 activity) (Fujita 2008)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

text	development of nervous (visual) system

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

ligand for neogenin (NEO1)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS