Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | NR3C2 | contributors: mct - updated : 24-09-2016 |
HGNC name | nuclear receptor subfamily 3, group C, member 2 |
HGNC id | 7979 |
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Corresponding disease |
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Location | 4q31 Physical location : 148.999.915 - 149.363.672 | ||||
Synonym name | mineralocorticoid receptor | ||||
Synonym symbol(s) | MLR |
DNA |
TYPE | functioning gene |
STRUCTURE | 363.00 kb 9 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
constitutive of |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
organ(s) |
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tissue |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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HOMOLOGY |
Homologene |
FAMILY | |
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CATEGORY | transcription factor , receptor nuclear |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus |
basic FUNCTION | |
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CELLULAR PROCESS | nucleotide, transcription, regulation |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein |
cell & other | binding to aldosterone |
REGULATION |
activated by | aldosterone |
progesterone and steroids lacking 21-hydroxyl groups (constitutively when mutated) |
ASSOCIATED DISORDERS |
corresponding disease(s) | PHA1A2 , NR3C2 |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |