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FLASH GENE
Symbol LDHD contributors: - updated : 20-04-2004
HGNC name lactate dehydrogenase D
HGNC id 19708
Location 16q22.3      Physical location : 75.145.758 - 75.150.665
Synonym symbol(s) MGC57726
EC.number 1.1.1.28
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- splicing 2091 - 507 - Flick
precursor
- splicing 2022 51 484 - Flick
precursor, lacks an in-frame segment compared to variant 1, resulting in a shorter isoform
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a putative mitochondrial targeting signal (MTS), a FAD binding domain
HOMOLOGY
interspecies ortholog to murine Ldhd
Homologene
FAMILY D isomer specific 2-hydroxyacid dehydrogenase family
CATEGORY enzyme , transport
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,mitochondria
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,peroxisome
basic FUNCTION
  • ATP bionsynthesis activity
  • may be involved in electron transport
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism energetic
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein binding specifically to the LIM domain of CRP3
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS