protein
| NFKB1 to repress NFKB1 responsive genes |
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with TP53 and enhancing its activity as a trancription factor (the binding of ING4 to TP53 is necessary for the function of ING4) |
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interacts with methylated histone H3 and with the MYST2-PHF17-MEAF6 histone acetyltransferase complex |
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ING4-MYST2 association is required for cells to progress properly through the DNA synthesis (S) phase of the cell cycle |
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downstream target of BRMS1 in regulating tumor angiogenesis |
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Epstein-Barr virus (EBV)-encoded EBNA3C significantly suppresses both the ING4- and ING5-mediated regulation of TP53 transcriptional activity in a dose-dependent manner |
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binding of PADI4 to ING4 stabilizes ING4 and protects it from rapid degradation (protein binding occurs through the IgG-like domains of PADI4 and the PHD finger of ING4) |
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ING4 acts as an E3 ubiquitin ligase to induce ubiquitination of RELA and degradation, which is critical to terminate NFKB activation |
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ARL6IP5 has an important role in ING4-regulated melanoma angiogenesis |
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RAS downregulated thymine-DNA glycosylase (TDG), a DNA demethylation enzyme, by inhibiting the interaction of transcription activator ING4 with TDG promoter |
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ZBTB17 is a newly identified ING4-induced target gene which can drive prostate luminal epithelial cell differentiation |