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FLASH GENE

Symbol

CEP68

contributors: mct/npt - updated : 20-02-2018

HGNC name	centrosomal protein 68kDa
HGNC id	29076

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2p14      Physical location : 65.283.494 - 65.314.141
Synonym name	KIAA0582 protein
	Cep68 protein
Synonym symbol(s)	KIAA0582, FLJ25920, FLJ36750

DNA

TYPE	functioning gene
STRUCTURE	30.65 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_015147 7 - 5877 NP_055962 - 757 - 2015 25704143 NM_001319100 7 - 5873 NP_001306029 - 757 - 2015 25704143 NM_001319101 7 - 5466 NP_001306030 - 620 - 2015 25704143

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage
cell lines
fluid/secretion	lymph

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal 300-400 AAs of CEP68 are necessary to localize CEP68 to interphase centrosomes while C-terminal 400-500 AAs might regulate CEP68 dissociation from centrosomes at mitotic onset

HOMOLOGY

Homologene

FAMILY

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	plasma membrane,junction
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus
text	AKAP9 spans the bridge between centrioles, co-localizing with CROCC and CEP68 in the linker region

basic FUNCTION	similar to CROCC, decorates fibres emanating from the proximal ends of centrioles and dissociates from centrosomes during mitosis (Graser 2007)
	cooperates with CROCC and CEP250 in centrosome cohesion (Graser 2007)
	is essential for centrosome cohesion and dissociates from centrosomes at the onset of mitosis
	role in the control of centrosome separation during mitosis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

centrosome cohesion is maintained by the newly identified complex of CEP250-CNTLN-CEP68

INTERACTION

DNA

RNA

small molecule

protein	CNTLN localizes to the proximal ends of the centrioles and directly interacts with both CEP250 and CEP68
	centriolar protein CNTLN functions as a molecular link between CEP250 and CEP68 to maintain centrosome cohesion
	absence of CROCC triggers the von Hippel-Lindau tumour suppressor protein (VHL)-mediated proteasomal degradation of CEP68 and, in turn, results in centrosome splitting
	archetypal linker protein CROCC maintains centrosome cohesion in part through inhibition of VHL-mediated CEP68 degradation
	as a result of MCM7 overexpression, CEP68 was targeted for ubiquitination and proteasomal degradation, thereby rendering centrosome splitting
	MCM7 directly complexes with CEP68 and VHL
	CEP68 interacts with the distal C-terminal AKAP9 region

cell & other

REGULATION

Phosphorylated by

NEK2 (NEK2 was demonstrated to phosphorylate CEP68 and this phosphorylation appears to promote CEP68 degradation in mitosis)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS