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FLASH GENE
Symbol CDC40 contributors: - updated : 09-09-2003
HGNC name cell division cycle 40 homolog (yeast)
HGNC id 17350
Location 6q22.1      Physical location : 110.501.623 - 110.553.420
Synonym symbol(s) EHB3, PRP17, PRPF17, FLJ10564
DNA
TYPE functioning gene
STRUCTURE 51.00 kb     17 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   moderately
Endocrinepancreas   highly
Nervousbrain   moderately
Reproductivemale systemprostate  moderately
Respiratorylung   moderately
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven WD repeats
HOMOLOGY
interspecies homolog to yeast S.cerevisiae Prp17 protein and F49D11.1
homolog to Xenopus Xl.11206
homolog to Drosophila CG6015
Homologene
FAMILY
CATEGORY regulatory , RNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION involved in pre-mRNA splicing and cell cycle progression
CELLULAR PROCESS cell cycle, progression
nucleotide, RNA splicing
PHYSIOLOGICAL PROCESS
text being essential for the catalytic step II in pre-mRNA splicing process
PATHWAY
metabolism
signaling
a component component of the spliceosome
INTERACTION
DNA
RNA
small molecule
protein binding to EH domain
cell & other
REGULATION
ASSOCIATED DISORDERS
ANIMAL & CELL MODELS