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FLASH GENE
Symbol SERPINA9 contributors: mct/npt - updated : 29-09-2009
HGNC name serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
HGNC id 15995
Location 14q32.13      Physical location : 94.929.059 - 94.942.670
Synonym name
  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9
  • centerin
  • germinal center B cell-expressed transcript 1
  • serine proteinase inhibitor A11
  • Synonym symbol(s) CENTERIN, GCET1, MGC131906, SERPINA11, SERPINA11b
    DNA
    TYPE functioning gene
    STRUCTURE 13.61 kb     6 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 1551 - 335 - Paterson (2007)
    5 - 1851 - 435 - Paterson (2007)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/ImmuneB cell
    cell lineage germinal center B-cell
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • serpin family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • protease inhibitor with expression restricted to germinal center B cells and lymphoid malignancies with germinal center B-cell maturation (Paterson 2008)
  • likely to function in the germinal centre as an efficient inhibitor of a trypsin-like protease (Paterson 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in most follicular lymphomas (Paterson 2008)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS