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FLASH GENE

Symbol

SEC61A1

contributors: npt/mct - updated : 25-08-2019

HGNC name	Sec61 alpha 1 subunit (S. cerevisiae)
HGNC id	18276

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	HNFJ4 hyperuricemic nephropathy, familial juvenile 4
Location	3q21.3      Physical location : 127.771.211 - 127.790.525
Synonym name	protein transport protein SEC61 alpha subunit isoform 1
	sec61 homolog
Synonym symbol(s)	HSEC61, SEC61A, HNFJ4, SEC61

DNA

TYPE	functioning gene
STRUCTURE	19.31 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_013336 12 - 3656 NP_037468 52.3 476 - 2009 19933108

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen       highly   thymus       predominantly Cardiovascular heart       moderately Digestive liver       highly Endocrine pancreas       highly Nervous brain       highly Reproductive male system prostate     highly Respiratory lung       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Lymphoid

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	ortholog to murine Sec61a
	homolog to yeast S.cerevisiae Sec61p
	homolog to E.coli SecYp
	homolog to C.elegans Y57G11C.15
	homolog to Drosophila Sec61alpha

Homologene

FAMILY

SECY/SEC61- alpha family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,granule
text	present in finely granular structures and was located exclusively in the ER

basic FUNCTION	playing a crutial role in the insertion of secretory and membrane polypeptides into the ER
	required for assembly of membrane and secretory proteins
	SEC61A1 complexes that are present in the ER membrane of nucleated cells form calcium leak channels that may play a crucial role in calcium homeostasis
	heterotrimeric SEC61A1 complex, which forms a dynamic polypeptide-conducting channel in the ER membrane
	role for SEC61A1 in the formation of the minimal filtration unit of the kidney, the nephron
	LONRF1, CDK1, RPL18, GNB2L1 (RACK1), RPL30, and SEC61A1 are crucial components in the diagnosis and treatment of Prostate carcinoma

CELLULAR PROCESS

protein, post translation, targeting

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	protein transport

PATHWAY

metabolism

signaling

a component

gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane

INTERACTION

DNA

RNA

small molecule

protein	HSPA5 limits ER Ca(2+) leakage through the SEC61A1 complex by binding to the ER lumenal loop 7 of Sec61A1 in the vicinity of tyrosine 344
	DNAJB11 associates with a large complex including SEC61A1
	co-chaperone-controlled gating of the SEC61A1 channel by HSPA5 is particularly important for cells, which are highly active in protein secretion, and breakdown of this regulatory mechanism can cause apoptosis and disease
	PEX3 inserts co-translationally into the mammalian ER via the SEC61A1 translocon

cell & other

tightly binding to membrane-bound ribosomes, either directly or through adapter proteins

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

HNFJ4

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	reliable molecular biomarker for the diagnosis of prostate carcinoma
Therapy target

ANIMAL & CELL MODELS